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KRAB zinc finger protein diversification drives mammalian interindividual methylation variability

KRAB zinc finger protein diversification drives mammalian interindividual methylation variability

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7733849

KRAB zinc finger protein diversification drives mammalian interindividual methylation variability

About this item

Full title

KRAB zinc finger protein diversification drives mammalian interindividual methylation variability

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (49), p.31290-31300

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Most transposable elements (TEs) in the mouse genome are heavily modified by DNA methylation and repressive histone modifications. However, a subset of TEs exhibit variable methylation levels in genetically identical individuals, and this is associated with epigenetically conferred phenotypic differences, environmental adaptability, and transgenera...

Alternative Titles

Full title

KRAB zinc finger protein diversification drives mammalian interindividual methylation variability

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7733849

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7733849

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2017053117

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