Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
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Author / Creator
Zhang, Jiasheng , Velmeshev, Dmitry , Hashimoto, Kei , Huang, Yu-Hsin , Hofmann, Jeffrey W. , Shi, Xiaoyu , Chen, Jiapei , Leidal, Andrew M. , Dishart, Julian G. , Cahill, Michelle K. , Kelley, Kevin W. , Liddelow, Shane A. , Seeley, William W. , Miller, Bruce L. , Walther, Tobias C. , Farese, Robert V. , Taylor, J. Paul , Ullian, Erik M. , Huang, Bo , Debnath, Jayanta , Wittmann, Torsten , Kriegstein, Arnold R. and Huang, Eric J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Aberrant aggregation of the RNA-binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by haploinsufficiency in the gene encoding progranulin
1
,
2
. However, the mechanism leading to TDP-43 proteinopathy remains unclear. Here we use single-nucleus RNA sequencing to show that progranulin deficiency p...
Alternative Titles
Full title
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
Authors, Artists and Contributors
Author / Creator
Velmeshev, Dmitry
Hashimoto, Kei
Huang, Yu-Hsin
Hofmann, Jeffrey W.
Shi, Xiaoyu
Chen, Jiapei
Leidal, Andrew M.
Dishart, Julian G.
Cahill, Michelle K.
Kelley, Kevin W.
Liddelow, Shane A.
Seeley, William W.
Miller, Bruce L.
Walther, Tobias C.
Farese, Robert V.
Taylor, J. Paul
Ullian, Erik M.
Huang, Bo
Debnath, Jayanta
Wittmann, Torsten
Kriegstein, Arnold R.
Huang, Eric J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7746606
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7746606
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2709-7
