Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells
About this item
Full title
Author / Creator
Baharom, Faezzah , Ramirez-Valdez, Ramiro A. , Tobin, Kennedy K. S. , Yamane, Hidehiro , Dutertre, Charles-Antoine , Khalilnezhad, Ahad , Reynoso, Glennys V. , Coble, Vincent L. , Lynn, Geoffrey M. , Mulè, Matthew P. , Martins, Andrew J. , Finnigan, John P. , Zhang, Xiao Meng , Hamerman, Jessica A. , Bhardwaj, Nina , Tsang, John S. , Hickman, Heather D. , Ginhoux, Florent , Ishizuka, Andrew S. and Seder, Robert A.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Personalized cancer vaccines are a promising approach for inducing T cell immunity to tumor neoantigens. Using a self-assembling nanoparticle vaccine that links neoantigen peptides to a Toll-like receptor 7/8 agonist (SNP-7/8a), we show how the route and dose alter the magnitude and quality of neoantigen-specific CD8
+
T cells. Intravenous va...
Alternative Titles
Full title
Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells
Authors, Artists and Contributors
Author / Creator
Ramirez-Valdez, Ramiro A.
Tobin, Kennedy K. S.
Yamane, Hidehiro
Dutertre, Charles-Antoine
Khalilnezhad, Ahad
Reynoso, Glennys V.
Coble, Vincent L.
Lynn, Geoffrey M.
Mulè, Matthew P.
Martins, Andrew J.
Finnigan, John P.
Zhang, Xiao Meng
Hamerman, Jessica A.
Bhardwaj, Nina
Tsang, John S.
Hickman, Heather D.
Ginhoux, Florent
Ishizuka, Andrew S.
Seder, Robert A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7746638
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7746638
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-020-00810-3
