Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the assistance of the substrate-binding 5-LOX-activating protein at the nuclear membrane. Here, we contrast the structural and functional consequences of the binding of two nat...
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Full title
Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7747934
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7747934
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-020-0544-7
