The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects
About this item
Full title
Author / Creator
Broekaart, Diede Wm , Bertran, Alexandra , Jia, Shaobo , Korotkov, Anatoly , Senkov, Oleg , Bongaarts, Anika , Mills, James D , Anink, Jasper J , Seco, Jesús , Baayen, Johannes C , Idema, Sander , Chabrol, Elodie , Becker, Albert J , Wadman, Wytse J , Tarragó, Teresa , Gorter, Jan A , Aronica, Eleonora , Prades, Roger , Dityatev, Alexander and van Vliet, Erwin A
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Matrix metalloproteinases (MMPs) are synthesized by neurons and glia and released into the extracellular space, where they act as modulators of neuroplasticity and neuroinflammatory agents. Development of epilepsy (epileptogenesis) is associated with increased expression of MMPs, and therefore, they may represent potential therapeutic drug targets....
Alternative Titles
Full title
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects
Authors, Artists and Contributors
Author / Creator
Bertran, Alexandra
Jia, Shaobo
Korotkov, Anatoly
Senkov, Oleg
Bongaarts, Anika
Mills, James D
Anink, Jasper J
Seco, Jesús
Baayen, Johannes C
Idema, Sander
Chabrol, Elodie
Becker, Albert J
Wadman, Wytse J
Tarragó, Teresa
Gorter, Jan A
Aronica, Eleonora
Prades, Roger
Dityatev, Alexander
van Vliet, Erwin A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7773344
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7773344
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI138332
