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AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7788527

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

About this item

Full title

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2020-04, Vol.580 (7805), p.647-652

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Neurodevelopment is characterized by rapid rates of neural cell proliferation and differentiation followed by massive cell death in which more than half of all recently generated brain cells are pruned back. Large amounts of DNA damage, cellular debris, and by-products of cellular stress are generated during these neurodevelopmental events, all of...

Alternative Titles

Full title

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7788527

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7788527

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-020-2174-3

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