SIRT1 is downregulated by autophagy in senescence and ageing
SIRT1 is downregulated by autophagy in senescence and ageing
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
SIRT1 (Sir2) is an NAD
+
-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, the immune response and ageing
1
–
5
. Although there is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the protein level is poorly understood. Here we report...
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Full title
SIRT1 is downregulated by autophagy in senescence and ageing
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7805578
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7805578
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ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/s41556-020-00579-5
