The NLRP3 inflammasome: molecular activation and regulation to therapeutics
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is an intracellular sensor that detects a broad range of microbial motifs, endogenous danger signals and environmental irritants, resulting in the formation and activation of the NLRP3 inflammasome. Assembly of the NLRP3 inflammasome leads to caspase 1-dependent release of the pro-inflammator...
Alternative Titles
Full title
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Authors, Artists and Contributors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7807242
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7807242
Other Identifiers
ISSN
1474-1733
E-ISSN
1474-1741
DOI
10.1038/s41577-019-0165-0
