The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating...
The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release
About this item
Full title
Author / Creator
Apicco, Daniel J. , Shlevkov, Evgeny , Nezich, Catherine L. , Tran, David T. , Guilmette, Edward , Nicholatos, Justin W. , Bantle, Collin M. , Chen, Yi , Glajch, Kelly E. , Abraham, Neeta A. , Dang, Lan T. , Kaynor, G. Campbell , Tsai, Ellen A. , Nguyen, Khanh-Dung H. , Groot, Joost , Liu, YuTing , Weihofen, Andreas , Hurt, Jessica A. , Runz, Heiko and Hirst, Warren D.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Inositol-1,4,5-triphosphate (IP₃) kinase B (ITPKB) is a ubiquitously expressed lipid kinase that inactivates IP₃, a secondary messenger that stimulates calcium release from the endoplasmic reticulum (ER). Genome-wide association studies have identified common variants in the ITPKB gene locus associated with reduced risk of sporadic Parkinson’s dise...
Alternative Titles
Full title
The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release
Authors, Artists and Contributors
Author / Creator
Shlevkov, Evgeny
Nezich, Catherine L.
Tran, David T.
Guilmette, Edward
Nicholatos, Justin W.
Bantle, Collin M.
Chen, Yi
Glajch, Kelly E.
Abraham, Neeta A.
Dang, Lan T.
Kaynor, G. Campbell
Tsai, Ellen A.
Nguyen, Khanh-Dung H.
Groot, Joost
Liu, YuTing
Weihofen, Andreas
Hurt, Jessica A.
Runz, Heiko
Hirst, Warren D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7817155
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7817155
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2006476118
