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Functional characterization of a PROTAC directed against BRAF mutant V600E

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Functional characterization of a PROTAC directed against BRAF mutant V600E

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7862923

Functional characterization of a PROTAC directed against BRAF mutant V600E

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New York: Nature Publishing Group US

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Contents

The RAF family kinases function in the RAS–ERK pathway to transmit signals from activated RAS to the downstream kinases MEK and ERK. This pathway regulates cell proliferation, differentiation and survival, enabling mutations in RAS and RAF to act as potent drivers of human cancers. Drugs targeting the prevalent oncogenic mutant BRAF(V600E) have sho...

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Functional characterization of a PROTAC directed against BRAF mutant V600E

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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7862923

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7862923

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ISSN

1552-4450

E-ISSN

1552-4469

DOI

10.1038/s41589-020-0609-7

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