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Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7865132

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

About this item

Full title

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (5), p.1-9

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown. To address this question, we performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify ge...

Alternative Titles

Full title

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7865132

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7865132

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2020478118

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