Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown. To address this question, we performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify ge...
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Full title
Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7865132
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7865132
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2020478118