Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
About this item
Full title
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development
1
,
2
. Cells that undergo WGD (WGD
+
cells) must adapt to accommodate their abnormal tetraploid state; however, the nature of these adaptations, and whether the...
Alternative Titles
Full title
Whole-genome doubling confers unique genetic vulnerabilities on tumour cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7889737
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7889737
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-03133-3
