Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by inducing the internalization and degradation of ferroportin
1
. Aberrant ferroportin activity can lead to diseases of iron overload, such as haemochromato...
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Full title
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7906036
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7906036
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2668-z
