Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids
Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
PQLC2, a lysosomal cationic amino acid transporter, also serves as a sensor that responds to scarcity of its substrates by recruiting a protein complex composed of C9orf72, SMCR8, and WDR41 to the surface of lysosomes. This protein complex controls multiple aspects of lysosome function. Although it is known that this response to changes in cationic...
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Full title
Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7923529
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7923529
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2014941118
