A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-indep...
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation
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Author / Creator
Schanin, Julia , Gebremeskel, Simon , Korver, Wouter , Falahati, Rustom , Butuci, Melina , Haw, Tatt Jhong , Nair, Prema M. , Liu, Gang , Hansbro, Nicole G. , Hansbro, Philip M. , Evensen, Erik , Brock, Emily C. , Xu, Alan , Wong, Alan , Leung, John , Bebbington, Christopher , Tomasevic, Nenad and Youngblood, Bradford A.
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
In addition to their well characterized role in mediating IgE-dependent allergic diseases, aberrant accumulation and activation of mast cells (MCs) is associated with many non-allergic inflammatory diseases, whereby their activation is likely triggered by non-IgE stimuli (e.g., IL-33). Siglec-8 is an inhibitory receptor expressed on MCs and eosinop...
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Full title
A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7946634
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7946634
Other Identifiers
ISSN
1933-0219
E-ISSN
1935-3456
DOI
10.1038/s41385-020-00336-9
