Development of Novel Inhibitors Targeting the D-Box of the DNA Binding Domain of Androgen Receptor
Development of Novel Inhibitors Targeting the D-Box of the DNA Binding Domain of Androgen Receptor
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
The inhibition of the androgen receptor (AR) is an established strategy in prostate cancer (PCa) treatment until drug resistance develops either through mutations in the ligand-binding domain (LBD) portion of the receptor or its deletion. We previously identified a druggable pocket on the DNA binding domain (DBD) dimerization surface of the AR and...
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Full title
Development of Novel Inhibitors Targeting the D-Box of the DNA Binding Domain of Androgen Receptor
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958344
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958344
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms22052493
