Raf promotes dimerization of the Ras G-domain with increased allosteric connections
Raf promotes dimerization of the Ras G-domain with increased allosteric connections
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Ras dimerization is critical for Raf activation. Here we show that the Ras binding domain of Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid bilayers and, to a lesser extent, in solution as observed by size exclusion chromatography and confirmed by SAXS. Community network analysis based on molecular dynamic...
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Full title
Raf promotes dimerization of the Ras G-domain with increased allosteric connections
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958358
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958358
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.2015648118
