Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
The protein p53 is a crucial tumor suppressor, often called “the guardian of the genome”; however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity of mutant p53 has been ascribed to enhanced propensity to fibrillize and recruit other cancer fighting proteins in the fibrils, yet the pathways of fibril nucleation and g...
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Full title
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958401
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7958401
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2015618118
