G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperlocomotion and altered dopamine signaling. Thus, ADGRL3 is a potential target for treatment of neurop...
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Full title
G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7990041
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7990041
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-020-0617-7
