Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
About this item
Full title
Author / Creator
Watson, McLane J. , Vignali, Paolo D. A. , Mullett, Steven J. , Overacre-Delgoffe, Abigail E. , Peralta, Ronal M. , Grebinoski, Stephanie , Menk, Ashley V. , Rittenhouse, Natalie L. , DePeaux, Kristin , Whetstone, Ryan D. , Vignali, Dario A. A. , Hand, Timothy W. , Poholek, Amanda C. , Morrison, Brett M. , Rothstein, Jeffrey D. , Wendell, Stacy G. and Delgoffe, Greg M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Regulatory T (T
reg
) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these cells
1
,
2
. Tumour cells show deregulated metabolism, leading to a metabolite-depleted, hypoxic and acidi...
Alternative Titles
Full title
Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
Authors, Artists and Contributors
Author / Creator
Vignali, Paolo D. A.
Mullett, Steven J.
Overacre-Delgoffe, Abigail E.
Peralta, Ronal M.
Grebinoski, Stephanie
Menk, Ashley V.
Rittenhouse, Natalie L.
DePeaux, Kristin
Whetstone, Ryan D.
Vignali, Dario A. A.
Hand, Timothy W.
Poholek, Amanda C.
Morrison, Brett M.
Rothstein, Jeffrey D.
Wendell, Stacy G.
Delgoffe, Greg M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7990682
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7990682
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-03045-2
