Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability
Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability
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Author / Creator
De Smet, Maarten Aj , Lissoni, Alessio , Nezlobinsky, Timur , Wang, Nan , Dries, Eef , Pérez-Hernández, Marta , Lin, Xianming , Amoni, Matthew , Vervliet, Tim , Witschas, Katja , Rothenberg, Eli , Bultynck, Geert , Schulz, Rainer , Panfilov, Alexander V , Delmar, Mario , Sipido, Karin R and Leybaert, Luc
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Cx43, a major cardiac connexin, forms precursor hemichannels that accrue at the intercalated disc to assemble as gap junctions. While gap junctions are crucial for electrical conduction in the heart, little is known about the potential roles of hemichannels. Recent evidence suggests that inhibiting Cx43 hemichannel opening with Gap19 has antiarrhyt...
Alternative Titles
Full title
Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8011902
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8011902
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI137752
