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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8052632

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

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New York: Nature Publishing Group US

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Contents

Tumor-associated macrophages (TAMs) play an important role in the immune response to cancer, but the mechanisms by which the tumor microenvironment controls TAMs and T cell immunity are not completely understood. Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in TAMs to modulate their functio...

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Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8052632

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8052632

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ISSN

1097-6256

E-ISSN

1546-1726

DOI

10.1038/s41593-019-0370-y

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