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Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8092608

Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

About this item

Full title

Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (17), p.1-12

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Insulin and insulin-like growth factor 1 (IGF-1) receptors share many downstream signaling pathways but have unique biological effects. To define the molecular signals contributing to these distinct activities, we performed global phosphoproteomics on cells expressing either insulin receptor (IR), IGF-1 receptor (IGF1R), or chimeric IR-IGF1R recept...

Alternative Titles

Full title

Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8092608

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8092608

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2019474118

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