Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring
About this item
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Author / Creator
Zviran, Asaf , Schulman, Rafael C. , Shah, Minita , Hill, Steven T. K. , Deochand, Sunil , Khamnei, Cole C. , Maloney, Dillon , Patel, Kristofer , Liao, Will , Widman, Adam J. , Wong, Phillip , Callahan, Margaret K. , Ha, Gavin , Reed, Sarah , Rotem, Denisse , Frederick, Dennie , Sharova, Tatyana , Miao, Benchun , Kim, Tommy , Gydush, Greg , Rhoades, Justin , Huang, Kevin Y. , Omans, Nathaniel D. , Bolan, Patrick O. , Lipsky, Andrew H. , Ang, Chelston , Malbari, Murtaza , Spinelli, Catherine F. , Kazancioglu, Selena , Runnels, Alexi M. , Fennessey, Samantha , Stolte, Christian , Gaiti, Federico , Inghirami, Giorgio G. , Adalsteinsson, Viktor , Houck-Loomis, Brian , Ishii, Jennifer , Wolchok, Jedd D. , Boland, Genevieve , Robine, Nicolas , Altorki, Nasser K. and Landau, Dan A.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restricts low-disease-burden monitoring through the prevailing deep targeted sequencing paradigm. We...
Alternative Titles
Full title
Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring
Authors, Artists and Contributors
Author / Creator
Schulman, Rafael C.
Shah, Minita
Hill, Steven T. K.
Deochand, Sunil
Khamnei, Cole C.
Maloney, Dillon
Patel, Kristofer
Liao, Will
Widman, Adam J.
Wong, Phillip
Callahan, Margaret K.
Ha, Gavin
Reed, Sarah
Rotem, Denisse
Frederick, Dennie
Sharova, Tatyana
Miao, Benchun
Kim, Tommy
Gydush, Greg
Rhoades, Justin
Huang, Kevin Y.
Omans, Nathaniel D.
Bolan, Patrick O.
Lipsky, Andrew H.
Ang, Chelston
Malbari, Murtaza
Spinelli, Catherine F.
Kazancioglu, Selena
Runnels, Alexi M.
Fennessey, Samantha
Stolte, Christian
Gaiti, Federico
Inghirami, Giorgio G.
Adalsteinsson, Viktor
Houck-Loomis, Brian
Ishii, Jennifer
Wolchok, Jedd D.
Boland, Genevieve
Robine, Nicolas
Altorki, Nasser K.
Landau, Dan A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8108131
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8108131
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/s41591-020-0915-3
