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[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8113290

[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

About this item

Full title

[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

European journal of nuclear medicine and molecular imaging, 2021-06, Vol.48 (6), p.1759-1772

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Purpose
Deposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect pathological aggregates of αSYN remains lacking. Here, we report the development of a positron emission tomography (PET) tracer based on anle138b, a compound shown to...

Alternative Titles

Full title

[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8113290

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8113290

Other Identifiers

ISSN

1619-7070

E-ISSN

1619-7089

DOI

10.1007/s00259-020-05133-x

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