CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneratio...
CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration
About this item
Full title
Author / Creator
Peng, Shaohong , Guo, Pei , Lin, Xiao , An, Ying , Sze, Kong Hung , Lau, Matthew Ho Yan , Chen, Zhefan Stephen , Wang, Qianwen , Li, Wen , Sun, Jacquelyne Ka-Li , Ma, Sum Yi , Chan, Ting-Fung , Lau, Kwok-Fai , Ngo, Jacky Chi Ki , Kwan, Kin Ming , Wong, Chun-Ho , Lam, Sik Lok , Zimmerman, Steven C. , Tuccinardi, Tiziano , Zuo, Zhong , Au-Yeung, Ho Yu , Chow, Hei-Man and Chan, Ho Yin Edwin
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
DNA damage plays a central role in the cellular pathogenesis of polyglutamine (polyQ) diseases, including Huntington’s disease (HD). In this study, we showed that the expression of untranslatable expanded CAG RNA per se induced the cellular DNA damage response pathway. By means of RNA sequencing (RNA-seq), we found that expression of the Nudix hydr...
Alternative Titles
Full title
CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration
Authors, Artists and Contributors
Author / Creator
Guo, Pei
Lin, Xiao
An, Ying
Sze, Kong Hung
Lau, Matthew Ho Yan
Chen, Zhefan Stephen
Wang, Qianwen
Li, Wen
Sun, Jacquelyne Ka-Li
Ma, Sum Yi
Chan, Ting-Fung
Lau, Kwok-Fai
Ngo, Jacky Chi Ki
Kwan, Kin Ming
Wong, Chun-Ho
Lam, Sik Lok
Zimmerman, Steven C.
Tuccinardi, Tiziano
Zuo, Zhong
Au-Yeung, Ho Yu
Chow, Hei-Man
Chan, Ho Yin Edwin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8126783
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8126783
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/PNAS.2022940118
