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28 results for Chan,+Ho+Yin+Edwin

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Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
Author / Creator:Zhao, Lei ; Li, Zhongqi ; Vong, Joaquim S. L. ; Chen, Xinyi ; Lai, Hei-Ming ; Yan, Leo Y. C. ; Huang, Junzhe ; Sy, Samuel K. H. ; Tian, Xiaoyu ; Huang, Yu ; Chan, Ho Yin Edwin ; So, Hon-Cheong ; Ng, Wai-Lung ; Tang, Yamei ; Lin, Wei-Jye ; Mok, Vincent C. T. ; Ko, Ho
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-09, Vol.11 (1), p.4413-15, Article 4413
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A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3
Author / Creator:Chen, Zhefan Stephen ; Huang, Xiaoying ; Talbot, Kevin ; Chan, Ho Yin Edwin
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2021-02, Vol.12 (2), p.136-19, Article 136
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Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD
Author / Creator:Chen, Zhefan Stephen ; Ou, Mingxi ; Taylor, Stephanie ; Dafinca, Ruxandra ; Peng, Shaohong Isaac ; Talbot, Kevin ; Chan, Ho Yin Edwin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-12, Vol.14 (1), p.8420-8420, Article 8420
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Expression of Expanded CAG Transcripts Triggers Nucleolar Stress in Huntington's Disease
Author / Creator:Tsoi, Ho ; Chan, Ho Yin Edwin
Publisher:New York: Springer-Verlag
Journal title:Cerebellum (London, England), 2013-06, Vol.12 (3), p.310-312
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Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor for Its Brain Uptake Enhancement
Author / Creator:Li, Jiahao ; Leung, Sharon Shui Yee ; Chan, Edwin Ho Yin ; Jiang, Cuiping ; Ho, Evelyn Tze Yin ; Zuo, Zhong
Publisher:New Zealand: Taylor & Francis Ltd
Journal title:International journal of nanomedicine, 2025-01, Vol.20, p.3945-3959
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CAG expansion induces nucleolar stress in polyglutamine diseases
Author / Creator:Tsoi, Ho ; Lau, Terrence Chi-Kong ; Tsang, Suk-Ying ; Lau, Kwok-Fai ; Chan, Ho Yin Edwin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (33), p.13428-13433
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RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis
Author / Creator:Chan, Ho Yin Edwin
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in cellular neuroscience, 2014-12, Vol.8, p.431-431
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Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5
Author / Creator:Chen, Zhefan Stephen ; Peng, Shaohong Isaac ; Leong, Lok I ; Gall-Duncan, Terence ; Wong, Nathan Siu Jun ; Li, Tsz Ho ; Lin, Xiao ; Wei, Yuming ; Koon, Alex Chun ; Huang, Junzhe ; Sun, Jacquelyne Ka-Li ; Turner, Clinton ; Tippett, Lynette ; Curtis, Maurice A. ; Faull, Richard L. M. ; Kwan, Kin Ming ; Chow, Hei-Man ; Ko, Ho ; Chan, Ting-Fung ; Talbot, Kevin ; Pearson, Christopher E. ; Chan, Ho Yin Edwin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-04, Vol.16 (1), p.3307-18, Article 3307
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MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods
Author / Creator:Qu, Zhe ; Bendena, William G. ; Nong, Wenyan ; Siggens, Kenneth W. ; Noriega, Fernando G. ; Kai, Zhen-peng ; Zang, Yang-yang ; Koon, Alex C. ; Chan, Ho Yin Edwin ; Chan, Ting Fung ; Chu, Ka Hou ; Lam, Hon Ming ; Akam, Michael ; Tobe, Stephen S. ; Lam Hui, Jerome Ho
Publisher:England: The Royal Society
Journal title:Proceedings of the Royal Society. B, Biological sciences, 2017-12, Vol.284 (1869), p.20171827-20171827
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Development of Fluorescent Turn-On Probes for CAG-RNA Repeats
Author / Creator:Lau, Matthew Ho Yan ; Wong, Chun-Ho ; Chan, Ho Yin Edwin ; Au-Yeung, Ho Yu
Publisher:Switzerland: MDPI AG
Journal title:Biosensors (Basel), 2022-11, Vol.12 (12), p.1080
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A heterozygous mutation in the CCDC88C gene likely causes early-onset pure hereditary spastic paraplegia: a case report
Author / Creator:Yahia, Ashraf ; Chen, Zhefan Stephen ; Ahmed, Ammar E. ; Emad, Sara ; Adil, Rawaa ; Abubaker, Rayan ; Taha, Shaimaa Omer M. A. ; Salih, Mustafa A. ; Elsayed, Liena ; Chan, Ho Yin Edwin ; Stevanin, Giovanni
Publisher:England: BioMed Central Ltd
Journal title:BMC neurology, 2021-02, Vol.21 (1), p.78-78, Article 78
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Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain?
Author / Creator:Chen, ZhefanStephen ; Chan, HoYin Edwin
Publisher:India: Medknow Publications and Media Pvt. Ltd
Journal title:Neural regeneration research, 2019-07, Vol.14 (7), p.1148-1151
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Sesamin extends the mean lifespan of fruit flies
Author / Creator:Zuo, Yuanyuan ; Peng, Cheng ; Liang, Yintong ; Ma, Ka Ying ; Chan, Ho Yin Edwin ; Huang, Yu ; Chen, Zhen-Yu
Publisher:Dordrecht: Springer Netherlands
Journal title:Biogerontology (Dordrecht), 2013-04, Vol.14 (2), p.107-119
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A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases
Author / Creator:Yu, Allen Chi-Shing ; Yim, Aldrin Kay-Yuen ; Chan, Anne Yin-Yan ; Yuen, Liz Y. P. ; Au, Wing Chi ; Cheng, Timothy H. T. ; Lin, Xiao ; Li, Jing-Woei ; Chan, Larry W. L. ; Mok, Vincent C. T. ; Chan, Ting-Fung ; Chan, Ho Yin Edwin
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroscience, 2019-12, Vol.13, p.1324-1324
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Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila
Author / Creator:Zhang, Qian ; Tsoi, Ho ; Peng, Shaohong ; Li, Pan P ; Lau, Kwok-Fai ; Rudnicki, Dobrila D ; Ngo, Jacky Chi-Ki ; Chan, Ho Yin Edwin
Publisher:England: The Company of Biologists Ltd
Journal title:Disease models & mechanisms, 2016-03, Vol.9 (3), p.321-334
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Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases
Author / Creator:Koon, Alex C. ; Chan, Ho Yin Edwin
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in cellular neuroscience, 2017-03, Vol.11, p.70-70
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Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles
Author / Creator:Kim, Ma Rie ; Feng, Teng ; Zhang, Qian ; Chan, Ho Yin Edwin ; Chau, Ying
Publisher:Switzerland: MDPI AG
Journal title:Polymers, 2019-02, Vol.11 (2), p.288
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CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration
Author / Creator:Peng, Shaohong ; Guo, Pei ; Lin, Xiao ; An, Ying ; Sze, Kong Hung ; Lau, Matthew Ho Yan ; Chen, Zhefan Stephen ; Wang, Qianwen ; Li, Wen ; Sun, Jacquelyne Ka-Li ; Ma, Sum Yi ; Chan, Ting-Fung ; Lau, Kwok-Fai ; Ngo, Jacky Chi Ki ; Kwan, Kin Ming ; Wong, Chun-Ho ; Lam, Sik Lok ; Zimmerman, Steven C. ; Tuccinardi, Tiziano ; Zuo, Zhong ; Au-Yeung, Ho Yu ; Chow, Hei-Man ; Chan, Ho Yin Edwin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-05, Vol.118 (19), p.1-12
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IL‐4/STAT6 axis observed to reverse proliferative defect in SCA3 patient‐derived neural progenitor cells
Author / Creator:Chen, Francis M. ; Li, Huixian ; Chung, Dittman Lai‐Shun ; Mak, Angel T. L. ; Leung, Fung Ping ; Chan, Ho Yin Edwin ; Wong, Wing Tak
Publisher:Australia: Wiley Subscription Services, Inc
Journal title:Clinical and experimental pharmacology & physiology, 2024-01, Vol.51 (1), p.30-39
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A Peptidylic Inhibitor for Neutralizing r(GGGGCC)exp-Associated Neurodegeneration in C9ALS-FTD
Author / Creator:Zhang, Qian ; An, Ying ; Chen, Zhefan Stephen ; Koon, Alex Chun ; Lau, Kwok-Fai ; Ngo, Jacky Chi Ki ; Chan, Ho Yin Edwin
Publisher:United States: Elsevier Inc
Journal title:Molecular therapy. Nucleic acids, 2019-06, Vol.16, p.172-185
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Showing 1 to 20 of 28 results

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Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

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A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

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Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD

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Expression of Expanded CAG Transcripts Triggers Nucleolar Stress in Huntington's Disease

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Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor for Its Brain Uptake Enhancement

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CAG expansion induces nucleolar stress in polyglutamine diseases

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RNA-mediated pathogenic mechanisms in polyglutamine diseases and amyotrophic lateral sclerosis

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Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5

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MicroRNAs regulate the sesquiterpenoid hormonal pathway in Drosophila and other arthropods

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Development of Fluorescent Turn-On Probes for CAG-RNA Repeats

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A heterozygous mutation in the CCDC88C gene likely causes early-onset pure hereditary spastic paraplegia: a case report

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Transcriptional dysregulation in neurodegenerative diseases: Who tipped the balance of Yin Yang 1 in the brain?

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Sesamin extends the mean lifespan of fruit flies

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A Targeted Gene Panel That Covers Coding, Non-coding and Short Tandem Repeat Regions Improves the Diagnosis of Patients With Neurodegenerative Diseases

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Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

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Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular Diseases

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Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles

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CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration

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IL‐4/STAT6 axis observed to reverse proliferative defect in SCA3 patient‐derived neural progenitor cells

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A Peptidylic Inhibitor for Neutralizing r(GGGGCC)exp-Associated Neurodegeneration in C9ALS-FTD

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