Comprehensive characterization of protein–protein interactions perturbed by disease mutations
Comprehensive characterization of protein–protein interactions perturbed by disease mutations
About this item
Full title
Author / Creator
Cheng, Feixiong , Zhao, Junfei , Wang, Yang , Lu, Weiqiang , Liu, Zehui , Zhou, Yadi , Martin, William R. , Wang, Ruisheng , Huang, Jin , Hao, Tong , Yue, Hong , Ma, Jing , Hou, Yuan , Castrillon, Jessica A. , Fang, Jiansong , Lathia, Justin D. , Keri, Ruth A. , Lightstone, Felice C. , Antman, Elliott Marshall , Rabadan, Raul , Hill, David E. , Eng, Charis , Vidal, Marc , Loscalzo, Joseph and Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Technological and computational advances in genomics and interactomics have made it possible to identify how disease mutations perturb protein–protein interaction (PPI) networks within human cells. Here, we show that disease-associated germline variants are significantly enriched in sequences encoding PPI interfaces compared to variants identified...
Alternative Titles
Full title
Comprehensive characterization of protein–protein interactions perturbed by disease mutations
Authors, Artists and Contributors
Author / Creator
Zhao, Junfei
Wang, Yang
Lu, Weiqiang
Liu, Zehui
Zhou, Yadi
Martin, William R.
Wang, Ruisheng
Huang, Jin
Hao, Tong
Yue, Hong
Ma, Jing
Hou, Yuan
Castrillon, Jessica A.
Fang, Jiansong
Lathia, Justin D.
Keri, Ruth A.
Lightstone, Felice C.
Antman, Elliott Marshall
Rabadan, Raul
Hill, David E.
Eng, Charis
Vidal, Marc
Loscalzo, Joseph
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8237108
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8237108
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-020-00774-y
