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Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally diff...

Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally diff...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8298220

Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro

About this item

Full title

Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Archives of toxicology, 2021-08, Vol.95 (8), p.2815-2823

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Highly toxic organophosphorus nerve agents, especially the extremely stable and persistent V-type agents such as VX, still pose a threat to the human population and require effective medical countermeasures. Engineered mutants of the
Brevundimonas diminuta
phosphotriesterase (BdPTE) exhibit enhanced catalytic activities and have demonstrated...

Alternative Titles

Full title

Catalytic activity and stereoselectivity of engineered phosphotriesterases towards structurally different nerve agents in vitro

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8298220

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8298220

Other Identifiers

ISSN

0340-5761

E-ISSN

1432-0738

DOI

10.1007/s00204-021-03094-0

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