Tsc1 regulates tight junction independent of mTORC1
Tsc1 regulates tight junction independent of mTORC1
About this item
Full title
Author / Creator
Lai, Mingqiang , Zou, Wenchong , Han, Zelong , Zhou, Ling , Qiu, Zeyou , Chen, Juan , Zhang, Sheng , Lai, Pinglin , Li, Kai , Zhang, Yue , Liang, Li , Jiang, Yu , Zou, Zhipeng and Bai, Xiaochun
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor that functions together with Tsc2 to negatively regulate the mechanistic target of rapamycin complex 1 (mTORC1) activity. Here, we show that Tsc1 has a critical role in the tight junction (TJ) formation of epithelium, independent of its role in Tsc2 and mTORC1 regulation. When an epithelial...
Alternative Titles
Full title
Tsc1 regulates tight junction independent of mTORC1
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8325158
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8325158
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2020891118
