Heat-dependent opening of TRPV1 in the presence of capsaicin
Heat-dependent opening of TRPV1 in the presence of capsaicin
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Transient receptor potential vanilloid member 1 (TRPV1) is a Ca
2+
-permeable cation channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we have determined the structures of apo and capsaicin-bound full-length rat TRPV1 reconstituted into lipid nanodiscs over a range of temperatures. This has allowed us to v...
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Full title
Heat-dependent opening of TRPV1 in the presence of capsaicin
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8335751
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8335751
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-021-00616-3
