Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of...
Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways
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Author / Creator
Invrea, Federica , Punzi, Simona , Petti, Consalvo , Minelli, Rosalba , Peoples, Michael D. , Bristow, Christopher A. , Vurchio, Valentina , Corrado, Alessia , Bragoni, Alberto , Marchiò, Caterina , Bertotti, Andrea , Trusolino, Livio , Bardelli, Alberto , Isella, Claudio , Carugo, Alessandro , Draetta, Giulio F. and Medico, Enzo
Publisher
Basel: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Basel: MDPI AG
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Scope and Contents
Contents
Colorectal cancer (CRC) is a heterogeneous disease showing significant variability in clinical aggressiveness. Primary and acquired resistance limits the efficacy of available treatments, and identification of effective drug combinations is needed to further improve patients’ outcomes. We previously found that the NEDD8-activating enzyme inhibitor...
Alternative Titles
Full title
Synthetic Lethality Screening Highlights Colorectal Cancer Vulnerability to Concomitant Blockade of NEDD8 and EGFR Pathways
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8345131
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8345131
Other Identifiers
ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers13153805
