Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and grad...
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
About this item
Full title
Author / Creator
Bollen, Yannik , Stelloo, Ellen , van Leenen, Petra , van den Bos, Myrna , Ponsioen, Bas , Lu, Bingxin , van Roosmalen, Markus J. , Bolhaqueiro, Ana C. F. , Kimberley, Christopher , Mossner, Maximilian , Cross, William C. H. , Besselink, Nicolle J. M. , van der Roest, Bastiaan , Boymans, Sander , Oost, Koen C. , de Vries, Sippe G. , Rehmann, Holger , Cuppen, Edwin , Lens, Susanne M. A. , Kops, Geert J. P. L. , Kloosterman, Wigard P. , Terstappen, Leon W. M. M. , Barnes, Chris P. , Sottoriva, Andrea , Graham, Trevor A. and Snippert, Hugo J. G.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well understood, especially at single-cell resolution. Here, we present 3D Live-Seq—a protocol that integrates live-cell imaging of tumor organoid outgrowth and w...
Alternative Titles
Full title
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
Authors, Artists and Contributors
Author / Creator
Stelloo, Ellen
van Leenen, Petra
van den Bos, Myrna
Ponsioen, Bas
Lu, Bingxin
van Roosmalen, Markus J.
Bolhaqueiro, Ana C. F.
Kimberley, Christopher
Mossner, Maximilian
Cross, William C. H.
Besselink, Nicolle J. M.
van der Roest, Bastiaan
Boymans, Sander
Oost, Koen C.
de Vries, Sippe G.
Rehmann, Holger
Cuppen, Edwin
Lens, Susanne M. A.
Kops, Geert J. P. L.
Kloosterman, Wigard P.
Terstappen, Leon W. M. M.
Barnes, Chris P.
Sottoriva, Andrea
Graham, Trevor A.
Snippert, Hugo J. G.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8346364
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8346364
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00891-2
