Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation
Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation
About this item
Full title
Author / Creator
Embgenbroich, Maria , van der Zande, Hendrik J. P. , Hussaarts, Leonie , Schulte-Schrepping, Jonas , Pelgrom, Leonard R. , García-Tardón, Noemí , Schlautmann, Laura , Stoetzel, Isabel , Händler, Kristian , Lambooij, Joost M. , Zawistowska-Deniziak, Anna , Hoving, Lisa , de Ruiter, Karin , Wijngaarden, Marjolein A. , Pijl, Hanno , van Dijk, Ko Willems , Everts, Bart , van Harmelen, Vanessa , Yazdanbakhsh, Maria , Schultze, Joachim L. , Guigas, Bruno and Burgdorf, Sven
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Proinflammatory activation of macrophages in metabolic tissues is critically important in the induction of obesity-induced metaflammation. Here, we demonstrate that the soluble mannose receptor (sMR) plays a direct functional role in both macrophage activation and metaflammation. We show that sMR binds CD45 on macrophages and inhibits its phosphata...
Alternative Titles
Full title
Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation
Authors, Artists and Contributors
Author / Creator
van der Zande, Hendrik J. P.
Hussaarts, Leonie
Schulte-Schrepping, Jonas
Pelgrom, Leonard R.
García-Tardón, Noemí
Schlautmann, Laura
Stoetzel, Isabel
Händler, Kristian
Lambooij, Joost M.
Zawistowska-Deniziak, Anna
Hoving, Lisa
de Ruiter, Karin
Wijngaarden, Marjolein A.
Pijl, Hanno
van Dijk, Ko Willems
Everts, Bart
van Harmelen, Vanessa
Yazdanbakhsh, Maria
Schultze, Joachim L.
Guigas, Bruno
Burgdorf, Sven
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8346872
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8346872
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2103304118
