BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates e...
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
About this item
Full title
Author / Creator
Kong, Weimin , Dimitri, Alexander , Wang, Wenliang , Jung, In-Young , Ott, Christopher J , Fasolino, Maria , Wang, Yan , Kulikovskaya, Irina , Gupta, Minnal , Yoder, Todd , DeNizio, Jamie E , Everett, John K , Williams, Erik F , Xu, Jun , Scholler, John , Reich, Tyler J , Bhoj, Vijay G , Haines, Kathleen M , Maus, Marcela V , Melenhorst, J. Joseph , Young, Regina M , Jadlowsky, Julie K , Marcucci, Katherine T , Bradner, James E , Levine, Bruce L , Porter, David L , Bushman, Frederic D , Kohli, Rahul M , June, Carl H , Davis, Megan M , Lacey, Simon F , Vahedi, Golnaz and Fraietta, Joseph A
Publisher
Ann Arbor: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
Ann Arbor: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Chimeric antigen receptor (CAR) T cells have induced remarkable antitumor responses in B cell malignancies. Some patients do not respond because of T cell deficiencies that hamper the expansion, persistence, and effector function of these cells. We used longitudinal immune profiling to identify phenotypic and pharmacodynamic changes in CD19-directe...
Alternative Titles
Full title
BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
Authors, Artists and Contributors
Author / Creator
Dimitri, Alexander
Wang, Wenliang
Jung, In-Young
Ott, Christopher J
Fasolino, Maria
Wang, Yan
Kulikovskaya, Irina
Gupta, Minnal
Yoder, Todd
DeNizio, Jamie E
Everett, John K
Williams, Erik F
Xu, Jun
Scholler, John
Reich, Tyler J
Bhoj, Vijay G
Haines, Kathleen M
Maus, Marcela V
Melenhorst, J. Joseph
Young, Regina M
Jadlowsky, Julie K
Marcucci, Katherine T
Bradner, James E
Levine, Bruce L
Porter, David L
Bushman, Frederic D
Kohli, Rahul M
June, Carl H
Davis, Megan M
Lacey, Simon F
Vahedi, Golnaz
Fraietta, Joseph A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8363276
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8363276
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI145459
