Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The mixed lineage kinase domain-like protein (MLKL) has recently been identified as a key RIP3 (receptor interacting protein 3) downstream component of tumour necrosis factor (TNF)-induced necroptosis. MLKL is phosphorylated by RIP3 and is recruited to the necrosome through its interaction with RIP3. However, it is still unknown how MLKL mediates T...
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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8369836
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8369836
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2883
