An information-theory analysis of DNA methylation identifies converging genetic and epigenetic drive...
An information-theory analysis of DNA methylation identifies converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia
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Full title
Author / Creator
Koldobskiy, Michael A. , Jenkinson, Garrett , Abante, Jordi , DiBlasi, Varenka A. Rodriguez , Zhou, Weiqiang , Pujadas, Elisabet , Idrizi, Adrian , Tryggvadottir, Rakel , Callahan, Colin , Bonifant, Challice L. , Rabin, Karen R. , Brown, Patrick A. , Ji, Hongkai , Goutsias, John and Feinberg, Andrew P.
Journal title
Language
English
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Scope and Contents
Contents
In cancer, linking epigenetic alterations to drivers of transformation has been difficult, in part because DNA-methylation analyses must capture epigenetic variability, which is central to tumour heterogeneity and tumour plasticity. Here, by conducting a comprehensive analysis, based on information theory, of differences in methylation stochasticit...
Alternative Titles
Full title
An information-theory analysis of DNA methylation identifies converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8370714
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8370714
Other Identifiers
E-ISSN
2157-846X
DOI
10.1038/s41551-021-00703-2
