Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neon...
Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Adeno-associated virus (AAV) transduction efficiency and tropism are conventionally determined by high expression of a fluorescent reporter gene. Emerging data has suggested that such conventional methods may underestimate AAV transduction for cells in which reporter expression from AAV vectors is undetectable. To explore an alternative method that...
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Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8376643
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8376643
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ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/s41434-021-00223-3
