Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice
Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Patterned degeneration of Purkinje cells (PCs) can be observed in a wide range of neuropathologies, but mechanisms behind nonrandom cerebellar neurodegeneration remain unclear. Sphingolipid metabolism dyshomeostasis typically leads to PC neurodegeneration; hence, we questioned whether local sphingolipid balance underlies regional sensitivity to pat...
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Full title
Sphingolipid metabolism governs Purkinje cell patterned degeneration in Atxn1[82Q]/+ mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8433568
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8433568
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2016969118
