Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomple...
Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle
About this item
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Author / Creator
Bhardwaj, Gourav , Penniman, Christie M , Jena, Jayashree , Suarez Beltran, Pablo A , Foster, Collin , Poro, Kennedy , Junck, Taylor L , Hinton, Jr, Antentor O , Souvenir, Rhonda , Fuqua, Jordan D , Morales, Pablo E , Bravo-Sagua, Roberto , Sivitz, William I , Lira, Vitor A , Abel, E Dale and O'Neill, Brian T
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Decreased skeletal muscle strength and mitochondrial dysfunction are characteristic of diabetes. The actions of insulin and IGF-1 through the insulin receptor (IR) and IGF-1 receptor (IGF1R) maintain muscle mass via suppression of forkhead box O (FoxO) transcription factors, but whether FoxO activation coordinates atrophy in concert with mitochondr...
Alternative Titles
Full title
Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8439595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8439595
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI146415
