Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
About this item
Full title
Author / Creator
Robinson, Philip S. , Coorens, Tim H. H. , Palles, Claire , Mitchell, Emily , Abascal, Federico , Olafsson, Sigurgeir , Lee, Bernard C. H. , Lawson, Andrew R. J. , Lee-Six, Henry , Moore, Luiza , Sanders, Mathijs A. , Hewinson, James , Martin, Lynn , Pinna, Claudia M. A. , Galavotti, Sara , Rahbari, Raheleh , Campbell, Peter J. , Martincorena, Iñigo , Tomlinson, Ian and Stratton, Michael R.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Mutation accumulation in somatic cells contributes to cancer development and is proposed as a cause of aging. DNA polymerases Pol ε and Pol δ replicate DNA during cell division. However, in some cancers, defective proofreading due to acquired
POLE
/
POLD1
exonuclease domain mutations causes markedly elevated somatic mutation burdens wit...
Alternative Titles
Full title
Increased somatic mutation burdens in normal human cells due to defective DNA polymerases
Authors, Artists and Contributors
Author / Creator
Coorens, Tim H. H.
Palles, Claire
Mitchell, Emily
Abascal, Federico
Olafsson, Sigurgeir
Lee, Bernard C. H.
Lawson, Andrew R. J.
Lee-Six, Henry
Moore, Luiza
Sanders, Mathijs A.
Hewinson, James
Martin, Lynn
Pinna, Claudia M. A.
Galavotti, Sara
Rahbari, Raheleh
Campbell, Peter J.
Martincorena, Iñigo
Tomlinson, Ian
Stratton, Michael R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8492474
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8492474
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00930-y
