cAMP binding to closed pacemaker ion channels is non-cooperative
cAMP binding to closed pacemaker ion channels is non-cooperative
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Electrical activity in the brain and heart depends on rhythmic generation of action potentials by pacemaker ion channels (HCN) whose activity is regulated by cAMP binding
1
. Previous work has uncovered evidence for both positive and negative cooperativity in cAMP binding
2
,
3
, but such bulk measurements suffer from limited para...
Alternative Titles
Full title
cAMP binding to closed pacemaker ion channels is non-cooperative
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8513821
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8513821
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03686-x
