Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes t...
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk
About this item
Full title
Author / Creator
Miles, Amy E , Dos Santos, Fernanda C , Byrne, Enda M , Renteria, Miguel E , McIntosh, Andrew M , Adams, Mark J , Pistis, Giorgio , Castelao, Enrique , Preisig, Martin , Baune, Bernhard T , Schubert, K Oliver , Lewis, Cathryn M , Jones, Lisa A , Jones, Ian , Uher, Rudolf , Smoller, Jordan W , Perlis, Roy H , Levinson, Douglas F , Potash, James B , Weissman, Myrna M , Shi, Jianxin , Lewis, Glyn , Penninx, Brenda W J H , Boomsma, Dorret I , Hamilton, Steven P , Sibille, Etienne , Hariri, Ahmad R , Nikolova, Yuliya S and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Publisher
England: Nature Publishing Group
Journal title
Language
English
Formats
Publication information
Publisher
England: Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Studies in post-mortem human brain tissue have associated major depressive disorder (MDD) with cortical transcriptomic changes, whose potential in vivo impact remains unexplored. To address this translational gap, we recently developed a transcriptome-based polygenic risk score (T-PRS) based on common functional variants capturing 'depression-like'...
Alternative Titles
Full title
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk
Authors, Artists and Contributors
Author / Creator
Dos Santos, Fernanda C
Byrne, Enda M
Renteria, Miguel E
McIntosh, Andrew M
Adams, Mark J
Pistis, Giorgio
Castelao, Enrique
Preisig, Martin
Baune, Bernhard T
Schubert, K Oliver
Lewis, Cathryn M
Jones, Lisa A
Jones, Ian
Uher, Rudolf
Smoller, Jordan W
Perlis, Roy H
Levinson, Douglas F
Potash, James B
Weissman, Myrna M
Shi, Jianxin
Lewis, Glyn
Penninx, Brenda W J H
Boomsma, Dorret I
Hamilton, Steven P
Sibille, Etienne
Hariri, Ahmad R
Nikolova, Yuliya S
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8580972
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8580972
Other Identifiers
ISSN
0893-133X,1740-634X
E-ISSN
1740-634X
DOI
10.1038/s41386-021-01189-x
