Gasdermin D pore structure reveals preferential release of mature interleukin-1
Gasdermin D pore structure reveals preferential release of mature interleukin-1
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
As organelles of the innate immune system, inflammasomes activate caspase-1 and other inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive precursors of the interleukin (IL)-1 family to generate mature cytokines such as IL-1β and IL-18. Cleaved GSDMD forms transmembrane pores to enable the release of IL-1 and to dr...
Alternative Titles
Full title
Gasdermin D pore structure reveals preferential release of mature interleukin-1
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8588876
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8588876
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03478-3
