Exome sequencing and analysis of 454,787 UK Biobank participants
Exome sequencing and analysis of 454,787 UK Biobank participants
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Author / Creator
DiscovEHR , Regeneron Genetics Center , Backman, Joshua D. , Li, Alexander H. , Marcketta, Anthony , Sun, Dylan , Mbatchou, Joelle , Kessler, Michael D. , Benner, Christian , Liu, Daren , Locke, Adam E. , Balasubramanian, Suganthi , Yadav, Ashish , Banerjee, Nilanjana , Gillies, Christopher E. , Damask, Amy , Liu, Simon , Bai, Xiaodong , Hawes, Alicia , Maxwell, Evan , Gurski, Lauren , Watanabe, Kyoko , Kosmicki, Jack A. , Rajagopal, Veera , Mighty, Jason , Jones, Marcus , Mitnaul, Lyndon , Stahl, Eli , Coppola, Giovanni , Jorgenson, Eric , Habegger, Lukas , Salerno, William J. , Shuldiner, Alan R. , Lotta, Luca A. , Overton, John D. , Cantor, Michael N. , Reid, Jeffrey G. , Yancopoulos, George , Kang, Hyun M. , Marchini, Jonathan , Baras, Aris , Abecasis, Gonçalo R. and Ferreira, Manuel A. R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
A major goal in human genetics is to use natural variation to understand the phenotypic consequences of altering each protein-coding gene in the genome. Here we used exome sequencing
1
to explore protein-altering variants and their consequences in 454,787 participants in the UK Biobank study
2
. We identified 12 million coding variants,...
Alternative Titles
Full title
Exome sequencing and analysis of 454,787 UK Biobank participants
Authors, Artists and Contributors
Author / Creator
Regeneron Genetics Center
Backman, Joshua D.
Li, Alexander H.
Marcketta, Anthony
Sun, Dylan
Mbatchou, Joelle
Kessler, Michael D.
Benner, Christian
Liu, Daren
Locke, Adam E.
Balasubramanian, Suganthi
Yadav, Ashish
Banerjee, Nilanjana
Gillies, Christopher E.
Damask, Amy
Liu, Simon
Bai, Xiaodong
Hawes, Alicia
Maxwell, Evan
Gurski, Lauren
Watanabe, Kyoko
Kosmicki, Jack A.
Rajagopal, Veera
Mighty, Jason
Jones, Marcus
Mitnaul, Lyndon
Stahl, Eli
Coppola, Giovanni
Jorgenson, Eric
Habegger, Lukas
Salerno, William J.
Shuldiner, Alan R.
Lotta, Luca A.
Overton, John D.
Cantor, Michael N.
Reid, Jeffrey G.
Yancopoulos, George
Kang, Hyun M.
Marchini, Jonathan
Baras, Aris
Abecasis, Gonçalo R.
Ferreira, Manuel A. R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8596853
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8596853
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-04103-z
