Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of...
Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Son of Sevenless (SOS) is a Ras guanine nucleotide exchange factor (GEF) that plays a central role in numerous cellular signaling pathways. Like many other signaling molecules, SOS is autoinhibited in the cytosol and activates only after recruitment to the membrane. The mean activation time of individual SOS molecules has recently been measured to...
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Full title
Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8694064
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8694064
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2103598118
