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Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor...

Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8712421

Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families

About this item

Full title

Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families

Publisher

New York: Nature Publishing Group US

Journal title

Nature immunology, 2022-01, Vol.23 (1), p.122-134

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

T cell activation, a key early event in the adaptive immune response, is subject to elaborate transcriptional control. In the present study, we examined how the activities of eight major transcription factor (TF) families are integrated to shape the epigenome of naive and activated CD4 and CD8 T cells. By leveraging extensive polymorphisms in evolu...

Alternative Titles

Full title

Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8712421

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8712421

Other Identifiers

ISSN

1529-2908

E-ISSN

1529-2916

DOI

10.1038/s41590-021-01086-x

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