PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by...
PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway
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Publisher
Singapore: Springer Singapore
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Language
English
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Publisher
Singapore: Springer Singapore
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Contents
Recent studies show that intracellular accumulation of cholesterol leads to acquired resistance to gefitinib in non-small cell lung cancer (NSCLC) cells. In this study we investigated how to regulate the cholesterol levels in gefitinib-resistant NSCLC cells. We showed that intracellular cholesterol levels in gefitinib-resistant cell lines (PC-9/GR,...
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Full title
PPARα agonist fenofibrate relieves acquired resistance to gefitinib in non-small cell lung cancer by promoting apoptosis via PPARα/AMPK/AKT/FoxO1 pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8724268
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8724268
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ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/s41401-021-00638-z
