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Microglia contribute to the propagation of Aβ into unaffected brain tissue

Microglia contribute to the propagation of Aβ into unaffected brain tissue

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8737330

Microglia contribute to the propagation of Aβ into unaffected brain tissue

About this item

Full title

Microglia contribute to the propagation of Aβ into unaffected brain tissue

Publisher

New York: Nature Publishing Group US

Journal title

Nature neuroscience, 2022-01, Vol.25 (1), p.20-25

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduc...

Alternative Titles

Full title

Microglia contribute to the propagation of Aβ into unaffected brain tissue

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8737330

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8737330

Other Identifiers

ISSN

1097-6256

E-ISSN

1546-1726

DOI

10.1038/s41593-021-00951-0

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