Microglia contribute to the propagation of Aβ into unaffected brain tissue
Microglia contribute to the propagation of Aβ into unaffected brain tissue
About this item
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Author / Creator
d’Errico, Paolo , Ziegler-Waldkirch, Stephanie , Aires, Vanessa , Hoffmann, Philippe , Mezö, Charlotte , Erny, Daniel , Monasor, Laura Sebastian , Liebscher, Sabine , Ravi, Vidhya M. , Joseph, Kevin , Schnell, Oliver , Kierdorf, Katrin , Staszewski, Ori , Tahirovic, Sabina , Prinz, Marco and Meyer-Luehmann, Melanie
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Microglia appear activated in the vicinity of amyloid beta (Aβ) plaques, but whether microglia contribute to Aβ propagation into unaffected brain regions remains unknown. Using transplantation of wild-type (WT) neurons, we show that Aβ enters WT grafts, and that this is accompanied by microglia infiltration. Manipulation of microglia function reduc...
Alternative Titles
Full title
Microglia contribute to the propagation of Aβ into unaffected brain tissue
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8737330
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8737330
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-021-00951-0
