Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s di...
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mutations in pitrilysin metallopeptidase 1 (PITRM1), a mitochondrial protease involved in mitochondrial precursor processing and degradation, result in a slow-progressing syndrome characterized by cerebellar ataxia, psychotic episodes, and obsessive behavior, as well as cognitive decline. To investigate the pathogenetic mechanisms of mitochond...
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Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758476
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8758476
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1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-020-0807-4
